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[目的]探讨单唾液酸四已糖神经节苷脂钠注射液联合中药治疗糖尿病周围神经病变(DNP)的临床疗效。[方法]选取2009年6月～2010年6月某院收治的DNP患者60例,按随机数字表法分为观察组和对照组。对照组给予单唾液酸四已糖神经节苷脂钠注射液,观察组在此基础上加用中药。观察两组神经传导速度变化、临床疗效和不良反应。[结果]两组治疗后正中神经和腓总神经的MCV、SCV均显著升高(P﹤0.05),观察组较对照组升高更为显著(P﹤0.05);观察组总有效率为90.0%(27/30),对照组为66.7%(20/30),差异有统计学意义(P﹤0.05);两组均未发生不良反应。[结论]单唾液酸四已糖神经节苷脂钠注射液联合中药治疗DNP能显著提高疗效,无不良反应,值得临床推广应用。
[Objective] To investigate the clinical efficacy of sodium monosialoglucose ganglioside injection combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy (DNP). [Methods] Sixty DNP patients admitted in a hospital from June 2009 to June 2010 were divided into observation group and control group according to random number table. The control group was given monosialotetrahexosyl ganglioside sodium injection, the observation group on the basis of the use of traditional Chinese medicine. The changes of nerve conduction velocity, clinical efficacy and adverse reactions were observed in both groups. [Results] The MCV and SCV of the median nerve and the common peroneal nerve were significantly increased in both groups (P <0.05), and the observation group was more significant than the control group (P <0.05). The total effective rate in the observation group was 90.0 % (27/30) in the control group and 66.7% (20/30) in the control group, the difference was statistically significant (P <0.05). No adverse reactions occurred in both groups. [Conclusion] Monosialotetrahexosyl ganglioside sodium injection combined with traditional Chinese medicine treatment of DNP can significantly improve the efficacy, no adverse reactions, worthy of clinical application.