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目的 :探讨上皮钙粘蛋白 /连接素 (E cd/cat)复合体在膀胱癌中的表达及对判断膀胱癌的复发及预后的价值。方法 :应用免疫组织化学法 (SP法 )检测 72例膀胱移行细胞癌和 10例正常泌尿系移行上皮石蜡包埋标本中E cd/cat复合体的表达情况。结果 :10例正常泌尿系移行上皮E cd/cat复合体各组成成分均正常表达。膀胱移行细胞癌中E cd、α cat、β cat、γ cat异常表达率分别为5 6 .9% (4 1/ 72 )、4 4 .4 % (32 / 72 )、5 6 .9% (4 1/ 72 )、4 3.1% (31/ 72 )。E cd和cat表达具有显著相关性 (P<0 .0 1)。E cd/cat复合体异常表达率与膀胱癌的病理分级和临床分期密切相关 (P <0 .0 5 )。β cat的异常表达与所有肿瘤的复发相关 (P <0 .0 5 )。α cat异常表达与表浅肿瘤 (Tis～T1期 )的复发密切相关 (P <0 .0 1)。γ cat异常表达与肿瘤的生存预后密切相关 (P <0 .0 1)。结论 :E cd/cat复合体的异常表达与膀胱癌的分化和侵袭程度密切相关。β cat是膀胱肿瘤复发预后的较好指标。α cat是表浅肿瘤复发预后的较好指标。γ cat是膀胱癌生存预后的有价值指标。
Objective: To investigate the expression of E-cadherin / Catenin (E cd / cat) complex in bladder cancer and its value in judging the recurrence and prognosis of bladder cancer. Methods: The expression of E cd / cat complex was detected by immunohistochemistry (SP method) in 72 cases of transitional cell carcinoma of bladder and 10 cases of normal urinary system. Results: The components of E cd / cat complex in 10 cases of normal urinary system transitional epithelium were all expressed normally. The abnormal expression rates of E cd, α cat, β cat and γ cat in BTCC were 56.9% (41/72), 44.4% (32/72) and 56.9% 4 1/72), 4 3.1% (31/72). There was a significant correlation between E cd and cat expression (P <0.01). The abnormal expression of E cd / cat complex was closely related to the pathological grade and clinical stage of bladder cancer (P <0.05). The abnormal expression of β cat was associated with the recurrence of all tumors (P <0.05). The abnormal expression of α cat is closely related to the recurrence of superficial tumors (Tis ~ T1) (P <0.01). The abnormal expression of γ cat is closely related to the prognosis of the tumor (P <0.01). Conclusion: The abnormal expression of E cd / cat complex is closely related to the differentiation and invasion of bladder cancer. β cat is a good indicator of prognosis of bladder cancer recurrence. α cat is a good indicator of the prognosis of superficial tumor recurrence. γ cat is a valuable indicator of bladder cancer survival and prognosis.