OBJECTIVE: To analyze the correlation between acne and Northwest dryness syndrome in the Xinjiang region to provide an epidemiological foundation for the prevention and treatment of acne in the region. METHODS: The correlations among acne, clinical syndromes of Northwest dryness syndrome, and Northwest dryness syndrome were evaluated using the syndrome fitness index and canonical correlation analysis. RESULTS: The acne group had a Northwest dryness syndrome rate of 24.13%, and the control group 10.34%(χ2=7.733, P<0.01). There was no significant difference in the fitness index for acne and for the sub-syndromes of Northwest dryness syndrome(P> 0.05). The first canonical correlation coefficient was 0.5656(P<0.01). The acne-dependent variable group had the largest damp-heat syndrome load(0.8709), and the independent variable had the largest lung-heart-spleen pyretic dryness load(0.6766). CONCLUSION: Northwest dryness syndrome is a risk factor for acne in the Xinjiang region. Exogenous dryness and endogenous damp are frequently seen as subsyndromes in Northwest dryness syndrome in acne patients in the region. Acne was correlated with the damp-heat and lung-heart-spleen pyretic dryness sub-syndromes of Northwest dryness syndrome. OBJECTIVE: To analyze the correlation between acne and Northwest dryness syndrome in the Xinjiang region to provide an epidemiological foundation for the prevention and treatment of acne in the region. METHODS: The correlations among acne, clinical syndromes of Northwest dryness syndrome, and Northwest dryness syndrome were evaluated using the syndrome fitness index and canonical correlation analysis. RESULTS: The acne group had a Northwest dryness syndrome rate of 24.13%, and the control group 10.34% (χ2 = 7.733, P <0.01). There was no significant difference in the fitness index for acne and for the sub-syndromes of Northwest dryness syndrome (P> 0.05). The first canonical correlation coefficient was 0.5656 (P <0.01). The acne-dependent variable group had the largest damp-heat syndrome load , and the independent variable had the largest lung-heart-spleen pyretic dryness load (0.6766). CONCLUSION: Northwest dryness syndrome is a risk factor for acne in the Xinjiang region. Exogenous dr yness and endogenous damp are frequently seen as subsyndromes in Northwest dryness syndrome in acne patients in the region. Acne was correlated with the damp-heat and lung-heart-spleen pyretic dryness sub-syndromes of Northwest dryness syndrome.