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目的:评价TP方案治疗晚期非小细胞肺癌的疗效和毒副反应。方法:TP方案:紫杉醇(PaclitaxelPTX)150mg/m2,静脉点滴,第1天,持续3h,顺铂(CisplatinPDD)20mg/m2,静脉点滴,第1天~第5天,21d为1周期,2周期~3周期为1个疗程。结果:TP方案29例,完全缓解(CR)1例(3.4%),部分缓解(PR)12例(41.4%),稳定(SD)11例(37.9%),进展(PD)5例(17.2%),总有效率44.8%。TP方案剂量限制性毒性主要为脱发、周围神经毒性、关节肌肉疼痛、白细胞下降发生率分别为93.1%、72.4%和51.7%,无Ⅳ度反应,患者均能够较好地耐受,不影响化疗继续进行。结论:TP方案治疗晚期非小细胞肺癌疗效较好,毒性可耐受,有利于提高患者的生命质量延长生存期。
Objective: To evaluate the efficacy and side effects of TP regimen in the treatment of advanced non-small cell lung cancer. Methods: TP regimen: paclitaxel PTX 150mg / m2, intravenous drip on the first day for 3h, Cisplatin PDD 20mg / m2, intravenous drip, the first day to the fifth day, 21d for the 1 cycle, 2 cycles ~ 3 cycles for a course of treatment. Results: There were 29 cases of TP, 1 case of complete remission (CR), 12 cases of partial remission (PR), 11 cases of stable (SD), 37 cases of stable (SD) and 5 cases of progressive %), The total efficiency of 44.8%. The dose-limiting toxicity of TP regimen was mainly alopecia, peripheral neurotoxicity, joint and muscle pain, and the incidence of leukopenia were 93.1%, 72.4% and 51.7%, respectively. There was no grade IV response and the patients were well tolerated and did not affect chemotherapy keep going. Conclusion: The TP regimen is effective in treating advanced non-small cell lung cancer and its toxicity is tolerable, which is beneficial to improve the quality of life of patients and prolong the survival period.