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目的:探讨血小板衍化生长因子受体-ɑ(PDGFR-ɑ)在继发性骨髓纤维化骨髓组织中的表达及临床意义。方法:应用免疫组化染色法,检测继发性骨髓纤维化组、对照组骨髓组织中PDGFR-α的表达情况。结果:继发性骨髓纤维化组骨髓组织中PDGFR-α的表达明显高于对照组,差异有统计学意义(P<0.05)。结论:PDGFR-α可能与继发性骨髓纤维化的发生、发展存在一定关联。
Objective: To investigate the expression and clinical significance of platelet-derived growth factor receptor-ɑ (PDGFR-ɑ) in secondary myelofibrosis. Methods: Immunohistochemical staining was used to detect the expression of PDGFR-α in the bone marrow of secondary myelofibrosis group and control group. Results: The expression of PDGFR-α in the bone marrow of secondary myelofibrosis group was significantly higher than that of the control group (P <0.05). Conclusion: PDGFR-α may be related to the occurrence and development of secondary myelofibrosis.