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目的：探讨前列腺液中细胞因子（ Ｉ Ｌ６、 Ｔ Ｎ Ｆα）与慢性前列腺炎的关系。方法：对５５例患者按 Ｍ ｅａｒｅｓ Ｓｔａｍ ｅｙ 法分为慢性细菌组、非细菌组、前列腺痛组，１２例健康人为对照组，采用双抗体夹心 Ｅ Ｌ Ｉ Ｓ Ａ 法检测了前列腺液中细胞因子（ Ｉ Ｌ６、 Ｔ Ｎ Ｆα）水平，用 Ｓ Ａ Ｓ统计分析软件中非平衡数据的方差分析方法和 Ｓ Ｎ Ｋ 法（ Ｑ 检验）作均数间的两两比较。结果：① Ｔ Ｎ Ｆα在慢性细菌组、非细菌组、前列腺痛组与健康人组均有差异（ Ｐ＜ ００１），慢性细菌组明显高于非细菌组、前列腺痛组（ Ｐ＜ ００１）。在非细菌组、前列腺痛组之间无显著差异（ Ｐ＞ ００５）。② Ｉ Ｌ６在慢性细菌组、非细菌组、前列腺痛的三组中都有升高，与健康人组均有显著差异（ Ｐ＜ ００５）。在慢性细菌组、非细菌组、前列腺痛组的三组间无显著差异（ Ｐ＞ ００５）。结论：前列腺液中细胞因子（ Ｉ Ｌ６、 Ｔ Ｎ Ｆα）可能在慢性前列腺炎的发病中起重要作用，是慢性前列腺炎有价值的指标，对慢性前列腺炎诊断、分型有一定临床意义。
Objective: To investigate the relationship between prostatic fluid cytokines (I L 6, T N F α) and chronic prostatitis. Methods: Fifty-five patients were divided into chronic bacterial group, non-bacterial group, prostatic pain group and 12 healthy volunteers by Mares-Stam ey method. The double antibody sandwich ELISA method was used to detect the cells in prostatic fluid Factor (I L 6, T N ) levels, with S A S statistical analysis of the software ANOVA and S N K method (Q test) as a means of comparison between the two. Results: ① T N Fα was different in chronic bacterial group, non-bacterial group, prostatic pain group and healthy group (P <001), chronic bacterial group was significantly higher than non-bacterial group, and prostatic pain group (P <001). There was no significant difference between non-bacterial group and prostatic pain group (P> 005). ② IL-6 in the chronic bacterial group, non-bacterial group, prostate pain in all three groups have increased, and healthy group were significantly different (P <0 05). There was no significant difference among the three groups in chronic bacterial group, non-bacterial group and prostatic pain group (P> 005). Conclusion: Prostatic fluid cytokines (IL 6, T N F α) may play an important role in the pathogenesis of chronic prostatitis, chronic prostatitis is a valuable indicator of the diagnosis of chronic prostatitis, there is a certain type Clinical significance.