米非司酮与孕三烯酮对子宫内膜异位症患者术后性激素水平和妊娠率的影响

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目的应用米非司酮与孕三烯酮治疗子宫内膜异位症术后患者,探讨其对患者术后性激素水平及妊娠率的影响。方法选取2010年1月-2015年6月武汉商职医院收治的120例子宫内膜异位症患者,按照治疗方法不同将其随机分为观察组与对照组,每组各60例。所有患者均进行保守性手术治疗,对照组术后给予孕三烯酮治疗,观察组术后给予米非司酮治疗。对两组患者治疗后性激素水平、视觉模拟评分法(VAS)、妊娠率等进行比较。结果与治疗前比较,两组患者治疗后血清促卵泡激素(FSH)、孕酮(P)、雌二醇(E2)水平均明显降低,黄体生成素(LH)明显升高,治疗前后比较,差异有统计学意义(P<0.05),且观察组降低幅度显著优于对照组(P<0.05);观察组治疗总有效率为96.7%,对照组为71.7%,两组比较,差异有统计学意义(P<0.05);与治疗前相比,两组患者治疗后盆腔症状评分均明显降低(P<0.05),且观察组降低幅度显著优于对照组(P<0.05);在妊娠率方面,观察组较对照组明显升高(P<0.05)。结论与孕三烯酮相比,米非司酮治疗子宫内膜异位症的疗效更佳,能够有效缩小子宫内膜厚度,调节机体性激素水平,同时具有较高的妊娠率。 Objective To study the effect of mifepristone and gestrinone on postoperative patients with endometriosis, and to explore the effect on postoperative sex hormone level and pregnancy rate. Methods From January 2010 to June 2015, 120 patients with endometriosis admitted to Wuhan Commercial Hospital were randomly divided into observation group and control group with 60 cases in each group. All patients underwent conservative surgery, the control group was given gestrinone treatment, the observation group was treated with mifepristone. The levels of sex hormones, visual analogue scale (VAS), pregnancy rate and so on were compared between the two groups after treatment. Results Compared with those before treatment, the levels of serum FSH, P and E2 were significantly decreased and the LH was significantly increased in both groups before and after treatment. The difference was statistically significant (P <0.05), and the observation group was significantly better than the control group (P <0.05); the total effective rate was 96.7% in the observation group, 71.7% in the control group, the two groups, the difference was statistically (P <0.05). Compared with those before treatment, pelvic symptom scores of both groups were significantly decreased (P <0.05), and the reduction in the observation group was significantly better than the control group (P <0.05) The observation group was significantly higher than the control group (P <0.05). Conclusion Compared with gestrinone, mifepristone is more effective in treating endometriosis, which can effectively reduce the thickness of endometrium, regulate the level of sex hormones and have a higher pregnancy rate.
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