用RAI和RLISA法对25例急性淋巴细胞白血病患儿脑脊液肿瘤坏死因子（TNF）和可溶性白细胞介素2受体（SIL－2R）进行测定，10例中枢神经系统白血病（CNSL）患儿脑脊液中TNF及SIL－2R测定值均明显高于无CNSL的白血病患儿及对照儿（＜0．001），并且二者在CNSL患儿脑脊液中的增高程度呈正相关（r＝0．643，P＜0．05）。无CNSL组与对照组脑脊液TNF、SIL－2R的测定值相比无明显差别。提示监测急性淋巴细胞性白血病患儿脑脊液TNF或SIL－2R有助于CNSL的诊断。 The levels of tumor necrosis factor (TNF) and soluble interleukin 2 receptor (SIL-2R) in cerebrospinal fluid of 25 children with acute lymphoblastic leukemia were determined by RAI and RLISA. The levels of soluble interleukin 2 receptor TNF and SIL-2R were significantly higher in children with chronic leukemia than those without CNSL (P <0.001), and both of them were positively correlated with the degree of cerebrospinal fluid (r = 0.643, P < 0.05). No CNSL group and control group cerebrospinal fluid TNF, SIL-2R measured values ​​compared to no significant difference. It is suggested that the monitoring of cerebrospinal fluid TNF or SIL-2R in children with acute lymphoblastic leukemia is helpful for the diagnosis of CNSL.