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目的：探讨前列地尔注射液治疗急性脑梗死的临床疗效、安全性，并观察经颅多谱勒(TCD)检测大脑前动脉及大脑中动脉血流速度的变化。方法选择近年来诊冶的颈内动脉系统急性脑梗死病例90例，随机分为治疗组46例，对照组44例，两组均给予常规治疗，治疗组在此基础上加用前列地尔注射液10ug 静脉推注，每天1次；两组疗程均为14d。治疗前后观察神经功能缺损评分、临床疗效，并通过 TCD 观察颅内血管平均血流速度(Vm)与血管搏动指数(PI)的变化和不良反应。结果治疗组总有效率为93.47％，对照组总有效率为77.27％(P<0.05)。前列地尔治疗后神经功能缺损评分和生活能力等级较治疗前显著改善(均 P<0.05)，优于对照组(P<0.05)；与治疗前相比，Vm 显著增快、血管阻力显著降低(P<0.05)。结论前列地尔注射液是改善脑血流、治疗急性脑梗死的一种安全有效的药物，有临床推广应用价值。“,”Objective: to exPlore the forefront, injection theraPy in acute cerebral infarction clinical curative effect, safety, and watch the transcranial doPPler (TCD) detection before cerebral artery and middle cerebral artery blood flow velocity changes.Methods in recent years, cases of acute cerebral infarction of internal carotid artery system diagnosis and metallurgy of 90 cases were randomly divided into treatment grouP, 46 cases in the control grouP of 44 cases, two grouPs were given conventional treatment, treatment grouP on the basis of the total lead to er fluids 10 ug intravenous injection, 1 times a day;Two grouPs of a course of 14 d.Observe the nerve function defect scale before and after the treatment, the clinical curative effect, and through TCD observations of intracranial vascular average blood flow velocity (Vm), and the change of blood vessel Pulsation index (PI) and adverse reactions.Results: treatment grouP total effective rate was 93.47%, control grouP total effective rate was 77.27% (P<0.05).Front row, nerve function defect grade and living ability level after treatment than before treatment significantly imProved (both P<0.05),better than the control grouP (P<0.05);ComPared with before treatment, significantly faster Vm, vascular resistance decreased significantly (P<0.05).Conclusion lead to injection is to imProve cerebral blood flow, the treatment of acute cerebral infarction of a safe and effective drugs, have clinical aPPlication value.