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目的:优选戊己胃漂浮缓释片的提取方法。方法:采用高效液相色谱法测定,以芍药苷、盐酸小檗碱、吴茱萸碱及吴茱萸次碱的含量为指标,对提取方法、提取溶剂、提取溶剂浓度和提取时间进行考察。结果:优化的提取条件为以纯甲醇为提取溶剂,超声提取30min。结论:优化提取工艺简便、稳定合理可行,为戊己胃漂浮缓释片提取方法及质量控制提供了较好的实验依据。
Objective: To optimize the extraction of pentosidine floating tablets. Methods: The contents of paeoniflorin, berberine hydrochloride, evodiamine and rutaecarpine were determined by high performance liquid chromatography. The extraction methods, solvent extraction, solvent concentration and extraction time were investigated. Results: The optimum extraction conditions were pure methanol as extraction solvent and ultrasonic extraction for 30 min. Conclusion: The optimized extraction process is simple, stable and feasible, and provides a good experimental basis for the extraction method and quality control of pentosamil floating sustained-release tablets.