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目的观察不同剂量百草枯中毒(PQ)患者采用血液灌流(HP)治疗的疗效及对患者预后的影响。方法纳入2013年6月至2016年6月PQ中毒的38例患者,根据患者中毒剂量分为A组(<25ml)为10例,B组(25~40ml)为17例,C组(>40ml)为11例,比较三组患者经HP和常规治疗的疗效,并测定经HP治疗后的降钙素原(PCT)水平。结果 A组和C组经HP治疗与常规治疗(非HP治疗)预后对比无统计学意义(P>0.05),B组经HP治疗较非HP治疗死亡人数较少。经过HP治疗后,三组中C组PCT水平较其他两组低,对比具有统计学意义(P<0.05)。结论中毒剂量在25~40ml的患者经常规治疗后采用HP治疗可显著提高疗效并有效改善患者的预后,具有较高的临床应用价值。
Objective To observe the curative effect of hemoperfusion (HP) in patients with paraquat poisoning (PQ) and the prognosis of patients. Methods Thirty-eight patients with PQ poisoning from June 2013 to June 2016 were divided into group A (<25ml), group B (25-40ml), group C (> 40ml ) Was performed in 11 patients. The curative effect of HP and conventional therapy were compared among the three groups, and the level of procalcitonin (PCT) after HP treatment was determined. Results There was no significant difference in prognosis between group A and group C treated with HP and routine treatment (non-HP) (P> 0.05). Group B received less HP than non-HP treated group. After HP treatment, PCT levels in the three groups were lower than those in the other two groups, with statistical significance (P <0.05). Conclusion In patients with toxic dose of 25 ~ 40ml after conventional treatment with HP therapy can significantly improve the efficacy and effectively improve the prognosis of patients with high clinical value.