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采用高效液相色谱法，对前列腺中依诺沙星的测定和药动学进行了研究。固定相：Ｓｈｉｍａｄｚ－ＯＤＳ柱，流动相：甲醇－乙腈－０．１ｍｏｌ／Ｌ柠檬殴（４．５：１：９），检测器：ＳＰＤ－６ＡＶ，检测波长：２７２ｎｍ，流速：１．５ｍｌ／ｍｉｎ，标准曲线线性范围：０．５～５μｇ／ｍｌ，ｒ＝０．９９９６，平均回收率为９８．８％，ＲＳＤ为０．７％，用３Ｐ８７实用药代动力学程序进行数据处理，在前列腺中各药代动力学参数Ｔ＿（１／２Ｋｅ），Ｔ＿（ｐ，ｃ＿（ｍａｘ）），ＡＵＣ，Ｃｌ／Ｆ（ｓ）和Ｖｃ／Ｆ（ｃ）分别为２．２３ｈ，２．３７ｈ，７．４３μｇ／ｍｌ，３９．４７（ｈ·μｇ）／ｍｌ，１．２７Ｌ／（ｋｇ·ｈ）和４．０７Ｌ／ｋｇ，结果表明，依诺沙星很容易透渗到前列腺组织中去，前列腺药物浓度很高，为临床应用依诺沙星治疗前列腺炎提供了理论依据。
The determination of enoxacin in the prostate and its pharmacokinetics were studied by HPLC. Stationary phase: Shimadz-ODS column, mobile phase: methanol-acetonitrile -0.1 mol / L lemon beater (4.5: 1: 9) detector: SPD-6AV detection wavelength: min, the linear range of standard curve was 0.5-5μg / ml, r = 0.9996, the average recovery rate was 98.8%, RSD was 0.7%. Data were processed with 3P87 practical pharmacokinetic program. The pharmacokinetic parameters T_ (1 / 2Ke), T_ (p, c_max), AUC, Cl / F (s) and Vc / F (c) in prostate were 2.23h, 2.37h, 7.43μg / ml, 39.47 (h · μg) / ml, 1.27L / (kg · h) and 4.07L / kg, the results show that enoxacin easily penetrate into the prostate tissue, Prostate drug concentration is high for the clinical application of enoxacin prostatitis provides a theoretical basis.