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目的探讨初治肺结核患者血清结核抗体(TB-Ab)IgG检测的临床应用价值和其影响因素。方法回顾性调查1 911例初治涂阳肺结核患者血清TB-Ab IgG阳性率,并与同期涂阴患者健康人群进行对照;观察血清TB-Ab IgG阳性率与病灶范围大小,有无空洞,是否排菌及排菌量多少的关系,将所得数据作统计学处理;同时观察血清TB-Ab IgG与结核纯蛋白衍化物皮肤试验(PPD)二者之间有无相关性。结果初治涂阳肺结核患者血清结核抗体阳性率仅53.3%,初治涂阴者为20.5%,健康人群血清结核抗体阳性率0.4%;初治涂阳患者血清TB-Ab IgG的阳性率与病灶范围大小,空洞有无及排菌量多少均有密切关系。结论血清TB-Ab IgG检测在肺结核患者中的特异性和敏感性值得商榷,其临床应用和诊断价值有待进一步完善和提高。
Objective To investigate the clinical value and influencing factors of serum TB antibody (TB-Ab) IgG in patients with newly diagnosed pulmonary tuberculosis. Methods The positive rate of TB-Ab IgG in 1 911 newly diagnosed smear-positive pulmonary tuberculosis patients was retrospectively investigated. The positive rate of TB-Ab IgG was compared with that of healthy subjects in the smear- The relationship between the number of bacteria and bacteria discharge, the data for statistical analysis; at the same time observe the serum TB-Ab IgG and tuberculin derivative skin test (PPD) between the two have no correlation. Results The positive rate of serum TB antibody was only 53.3% in primary smear-positive pulmonary tuberculosis patients, 20.5% in primary smear-negative patients and 0.4% in healthy population. The positive rate of TB-Ab IgG in patients with smear- Size, empty presence and amount of bacteria are closely related. Conclusion The specificity and sensitivity of serum TB-Ab IgG in patients with pulmonary tuberculosis are debatable. The clinical application and diagnostic value need to be further improved.