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急性肾损伤(acute kidney injury,AKI)是临床上发病率和病死率都非常高的一种肾脏疾病。众所周知,肾脏的血供与氧供之间存在着明显的供需失衡。一方面,肾脏血供丰富,但由于解剖和生理原因,只有不到10%的肾脏血供供应肾髓质;另一方面,肾小管的主动重吸收需要大量氧供。这种供求失衡导致肾脏中线粒体丰富的近端肾小管极易遭受各种损伤而诱导AKI发生。目前有关AKI的治疗
Acute kidney injury (AKI) is a kidney disease with very high clinical morbidity and mortality. It is well-known that there is a clear imbalance between supply and demand of blood and oxygen supply in the kidney. On the one hand, the renal blood supply is plentiful, but less than 10% of the renal blood supply to the medulla for anatomic and physiological reasons; on the other hand, renal tubular reabsorption requires large amounts of oxygen. This imbalance between supply and demand leads to mitochondrial-rich proximal tubules in the kidney vulnerable to various injuries that induce AKI. The current treatment of AKI