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目的:探讨p33ING1和hTERT在新疆维族妇女宫颈鳞癌组织中的表达及其相互关系。方法:用免疫组化法检测SCC52例,CIN、CIS35例患者中p33ING1和hTERT表达,并用正常宫颈13例作为对照。结果:1)对照组、CINⅠ+Ⅱ级组、CINⅢ级+CIS组、SCC组p33ING1阳性率分别为84.6%、90.0%、64.0%、19.2%,SCC组阳性表达减少,与前三组有显著性差异(P<0.05);2)四组hTERT阳性率分别为15.4%、70.0%、96.0%、100%,SCC组阳性表达率明显增加,各组比较之间有统计学意义(P<0.05);3)宫颈组织中p33ING1和hTERT阳性表达呈负相关(P<0.05)。结论:新疆维族妇女宫颈癌组织中p33ING1表达减少,而hTERT表达增加,同时检测它们的表达,有助于宫颈癌的早期诊断。
Objective: To investigate the expression and correlation of p33ING1 and hTERT in Uigur women with cervical squamous cell carcinoma in Xinjiang. Methods: The expressions of p33ING1 and hTERT in 52 cases of SCC, 35 cases of CIN and CIS were detected by immunohistochemistry, and 13 cases of normal cervix were used as control. Results: 1) The positive rates of p33ING1 in control group, CINⅠ + Ⅱ group, CINⅢ + CIS group and SCC group were 84.6%, 90.0%, 64.0% and 19.2%, respectively. The positive expression of p33ING1 in SCC group was significantly lower than that in the other three groups (P <0.05); 2) The positive rates of hTERT in the four groups were 15.4%, 70.0%, 96.0% and 100% respectively, and the positive rates of SCC were significantly increased ); 3) The positive expression of p33ING1 and hTERT in cervical tissue was negatively correlated (P <0.05). Conclusion: The expression of p33ING1 in uterine cervix cancer tissues of Uygur women in Xinjiang is decreased, but the expression of hTERT is increased. Meanwhile, the expression of p33ING1 is detected, which is helpful for the early diagnosis of cervical cancer.