人单核细胞趋化蛋白－１（ＭＣＰ－１）是由多种细胞产生的一种趋化因子。它不但能趋化单核细胞还能激活单核细胞，在机体防御、炎症恢复和抗肿瘤等方面起重要作用。本文利用ＲＴ－ＰＣＲ方法克隆了人ＭＣＰ－１ｃＤＮＡ，经核苷酸序列测定，除第１２位密码子为ＴＧＴ与国外报道的ＴＧＣ不同、但编码相同的氨基酸半胱氨酸外，其余序列完全相同。 Human monocyte chemotactic protein-1 (MCP-1) is a chemokine produced by a variety of cells. It can not only chemotactic monocytes but also monocytes, play an important role in body defense, inflammation recovery and anti-tumor. In this study, human MCP-1 cDNA was cloned by RT-PCR. The nucleotide sequence of the human MCP-1 cDNA was cloned, except that TGT at position 12 was different from TGC reported in other countries, except for the amino acid cysteine .