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目的探究布拉氏酵母菌散联合传统四联疗法根除幽门螺杆菌(HP)的疗效及对血清炎症因子水平的影响。方法68例HP感染者随机数表法分组,各34例。对照组予以传统四联疗法,研究组予以布拉氏酵母菌和传统四联疗法,疗程14 d。统计临床效果,对比治疗前后血清白细胞介素-2、6(IL-2、6)、C-反应蛋白(CRP)]水平。结果研究组治疗总有效率94.12%(32/34)高于对照组64.71%(22/34)(P<0.05);治疗前两组血清炎症因子水平无差异(P>0.05),治疗后研究组IL-6、CRP水平低于对照组,IL-2水平高于对照组(P<0.05)。结论布拉氏酵母菌散联合传统四联疗法可有效根除HP,降低血清炎症因子水平。
Objective To investigate the curative effect of Blah’s yeast powder combined with traditional quadruple therapy on the eradication of Helicobacter pylori (HP) and its effect on the levels of serum inflammatory cytokines. Methods Sixty-eight patients with HP infection were randomly divided into three groups according to random number table. The control group was treated with traditional quadruple therapy, and the study group was given Brachyerella and traditional quadruple therapy for 14 days. The clinical effect was statistically analyzed. The levels of serum interleukin-2, 6 (IL-2, 6) and C-reactive protein (CRP) were compared before and after treatment. Results The total effective rate of the study group was 94.12% (32/34), which was significantly higher than that of the control group (64.71%, 22/34) (P <0.05). There was no difference in serum inflammatory cytokines between the two groups before treatment (P> 0.05) The levels of IL-6 and CRP were lower in the control group than those in the control group (P <0.05). Conclusion Blatcalisale combined with traditional quadruple therapy can effectively eradicate HP and reduce serum levels of inflammatory cytokines.