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目的比较局部晚期食管癌累积野照射与选择淋巴引流区照射的毒性反应与疗效。方法将60例局部晚期食管鳞癌患者按照数字表法随机分成两组:累积野照射组和选择淋巴引流区照射组。两组PTV照射50.4 Gy,共28次,PGTV照射59.36 Gy,共28次。两组均同期给予DF方案化疗2个周期。结果累积野照射组和选择淋巴引流区照射组1、2生存率分别是83%、65%和80%、59%,差异无统计学意义(χ2=0.064,P=0.317)。累积野照射组和选择淋巴引流区照射组有效率分别为93.3%(28/30)和96.6%(29/30),差异无统计学意义(χ2=0.867,P=0.335)。急性不良反应两组比较差异无统计学意义。结论局部晚期食管癌放射治疗时采用累积野照射与选择淋巴引流区照射疗效相同,急性不良反应相同,应进一步观察晚期损伤,放疗中应使用照射野较小的累积野照射。
Objective To compare the toxicity and efficacy of cumulative field radiation in locally advanced esophageal cancer with selective lymphatic drainage. Methods Sixty patients with locally advanced esophageal squamous cell carcinoma were randomly divided into two groups according to digital table: cumulative field irradiation group and selective lymphatic drainage group. Two groups of PTV irradiation 50.4 Gy, a total of 28 times, PGTV irradiation 59.36 Gy, a total of 28 times. Two groups were given concurrent chemotherapy DF 2 cycles. Results The survival rates of group 1,2 and group C were 83%, 65% and 80%, 59% respectively, with no significant difference (χ2 = 0.064, P = 0.317). The effective rates of cumulative field irradiation group and selective drainage group were 93.3% (28/30) and 96.6% (29/30) respectively, with no significant difference (χ2 = 0.867, P = 0.335). Acute adverse reactions were no significant difference between the two groups. Conclusion Radiation therapy of locally advanced esophageal cancer using cumulative field irradiation and selective lymphatic drainage area irradiation the same effect, the same acute adverse reactions, should be further observed late injury, radiotherapy should be used in the smaller field of radiation field exposure.