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目的探讨食管鳞状细胞癌并发食管胃肠间质瘤的临床病理学特征及鉴别诊断要点。方法观察1例食管癌并发食管间质瘤的病理形态和免疫组化特点,并进行文献复习和讨论。结果患者女性,77岁。进食哽噎20余天。巨检见食管黏膜局部有一息肉状肿物突入管腔,紧邻该肿物另见一溃疡型肿物;镜检见食管鳞状细胞癌细胞多为基底细胞型,呈巢状、弥漫排列,侵及肌层;食管间质瘤由梭形细胞和上皮样细胞组成,呈束状、编织状排列,病理核分裂象>10个/50HPF。免疫组化标记CD117呈强(+)。结论食管鳞状细胞癌并发食管间质瘤属少见的消化道恶性肿瘤,掌握临床病理及免疫组化特征对该病的诊断与鉴别诊断具有重要意义。
Objective To investigate the clinicopathological features and differential diagnosis of esophageal squamous cell carcinoma with esophageal gastrointestinal stromal tumors. Methods One case of esophageal carcinoma complicated with esophageal stromal tumors was studied by pathology and immunohistochemistry. Results Patients Female, 77 years old. Eat 哽 噎 more than 20 days. The giant esophageal mucosa with a look into the lucent of a fleshy tumor, close to the tumor See also a ulcerated tumor; microscopic examination esophageal squamous cell carcinoma mostly basal cell type, was nested, diffuse arrangement, invasion And muscularis propria. Esophageal stromal tumors consist of spindle cells and epithelioid cells in the form of bundles and weaves. The pathological mitosis is> 10/50 HPF. The immunohistochemical marker CD117 was strongly (+). Conclusions Esophageal squamous cell carcinoma complicated by esophageal stromal tumor is a rare malignant tumor of the digestive tract. It is of great significance to diagnose and differentiate the pathological and immunohistochemical features of the esophageal squamous cell carcinoma.