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《Science》、《Neuron》杂志于2008年同时报道了一项重要发现:成对性免疫球蛋白受体B(Paired immunoglobulin-like receptor B,PirB)是中枢神经系统髓磷脂抑制因子(Myelinassociated inhibitory proteins,MAIs):Nogo-A,髓鞘相关糖蛋白(Myelin-associated glycoprotein,MAG),少突胶质细胞髓磷脂糖蛋白(Oligodendrocyte myelin glycoprotein,OMgp)的共受体,它们具有高亲和力,结合后表现出抑制轴突生长的慢性抑制作用[1,2]。2012年Adelson等[3]在《Neuron》杂志中的报道显示,PirB表达下调有利于脑缺血再灌注损伤后皮质脊髓束的
In Science, Neuron magazine reported in 2008 one of the important findings: Paired immunoglobulin-like receptor B (PirB) is a central nervous system myelin inhibitory factor (Myelinassociated inhibitory proteins , MAIs): co-receptors of Nogo-A, Myelin-associated glycoprotein (MAG) and Oligodendrocyte myelin glycoprotein (OMgp), which have high affinity, Showed a chronic inhibition of axonal growth [1,2]. 2012 Adelson et al [3] in the “Neuron” magazine reports show that PirB downregulation of cerebral ischemia and reperfusion injury in favor of corticospinal tract