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目的:探讨反季节水果摄入与女童性早熟之间的相关关系,为进一步评价反季节水果的安全性提供线索。方法:采用以医院为基础的1∶1配对病例-对照研究方法,按同性别、年龄相差不超过1岁进行配对,收集性早熟女童及其他疾病患儿各105例。采用膳食频率问卷调查方法调查主要反季节水果的摄入量,进行单因素及多因素Logistic回归分析。结果:反季节水果暴露的总体情况病例组与对照组无统计学差异(P>0.05)。进一步按季节划分,经多因素分析发现水果因素中摄入春季的芒果、草莓、樱桃、甜橙,夏季的桃子过多,与女童发生性早熟正关联(P<0.05),而经常摄入夏季、冬季的葡萄,夏季的草莓和秋季的桃子、甜橙与其负关联(P<0.05)。非水果因素中禽畜肉类摄入情况与发生性早熟呈负相关(P<0.05),营养保健品服用史与其呈正相关(P<0.05),洋快餐及油炸食品摄入未见统计学差异(P>0.05)。结论:本研究未发现反季节水果的总体摄入与女童性早熟的关联性。但部分反季节水果过多摄入在女童性早熟发病中可能起促进作用,仍需进一步研究。
Objective: To explore the correlation between anti-seasonal fruit intake and precocious puberty in girls and provide clues for further evaluating the safety of anti-seasonal fruit. Methods: A hospital-based 1: 1 matched case-control study was conducted. Paired patients of the same sex and no more than 1 year of age were collected. 105 cases of precocious girls and other diseases were collected. The dietary frequency questionnaire survey was used to investigate the intake of main anti-seasonal fruits, and single factor and multivariate Logistic regression analysis. Results: The overall situation of anti-seasonal fruit exposure cases and control group no significant difference (P> 0.05). Further analysis showed that the intake of spring fruits such as mango, strawberry, cherry, orange and peach in summer was correlated with the occurrence of precocious puberty in girls (P <0.05) , Winter grapes, summer strawberries and autumn peaches, oranges were negatively associated with them (P <0.05). There was a negative correlation between the meat intake of livestock and the occurrence of precocious puberty (P <0.05), and the use of nutraceuticals was positively correlated with non-fruit factors (P <0.05), while the consumption of foreign fast food and fried food was not statistically significant Difference (P> 0.05). Conclusion: This study did not find the association of seasonal fruit intake with girl precocious puberty. However, some excessive intake of off-season fruit may play a promoting role in the precocious puberty of girls, and further research is needed.