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目的研究膀胱癌组织中IFLICE、PI、AI的表达与肿瘤分期、分级和类型的关系,探讨膀胱癌组织中肿瘤细胞增殖/凋亡失衡的状况,以及这些因素与病人预后的关系。方法采用免疫组化方法测定PI、AI、IFLICE在56例肿瘤标本中的表达,分析其表达与肿瘤组织学的关系,及对病人预后的影响。结果IFLICE、AI、PI的阳性表达在56个病例中分别为:64%、34%、59%。IFLICE在膀胱癌中的表达对肿瘤的分级和病人的预后有显著影响,而AI的表达无显著性意义。结论IFLICE对评价膀胱癌的侵袭性和预后是一个重要的独立因素,膀胱癌中肿瘤细胞增殖/凋亡的失衡是一种以增殖为主、凋亡相对受到抑制的失衡。
Objective To study the relationship between the expression of IFLICE, PI and AI in bladder cancer and tumor stage, grade and type, and to explore the imbalance of proliferation / apoptosis of tumor cells in bladder cancer and their relationship with prognosis. Methods Immunohistochemistry was used to determine the expression of PI, AI and IFLICE in 56 tumor samples. The relationship between the expression of PI, AI and IFLICE was analyzed. The relationship between the expression of PI, AI and IFLICE and the prognosis of patients was analyzed. Results The positive expression of IFLICE, AI and PI were 64%, 34% and 59% respectively in 56 cases. The expression of IFLICE in bladder cancer has a significant effect on the grade of the tumor and the prognosis of the patients, while the expression of AI has no significance. Conclusion IFLICE is an important independent factor in evaluating the invasiveness and prognosis of bladder cancer. The imbalance of proliferation / apoptosis of tumor cells in bladder cancer is an imbalance that is mainly proliferative and whose apoptosis is relatively inhibited.