论文部分内容阅读
目的探讨联合应用普罗布考和辛伐他汀对急性冠状动脉综合征(ACS)患者颈动脉内膜中层厚度和血管内皮功能的影响。方法急性冠状动脉综合征患者60例,随机分为单服辛伐他汀组(A组,辛伐他汀40mg/d,n=30)以及辛伐他汀及普罗布考联合治疗组(B组,辛伐他汀40mg/d,普罗布考0.5g,2次/d,n=30),检测外周血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及氧化低密度脂蛋白(ox-LDL)水平,用药治疗3个月,观察治疗前后的指标变化。应用高频超声检测颈动脉内膜中层厚度(CIMT)及肱动脉内皮依赖血管舒张功能(FMD),用药治疗3个月,观察治疗前后的指标变化。结果两组治疗前各项指标差异无统计学意义。治疗3月后两组患者外周血TC、LDL-C、ox-LDL、CIMT均较治疗前降低,FMD改善。但联合治疗组降低的幅度较单独治疗组大。结论对于ACS患者辛伐他汀合用抗氧化治疗能进一步降低血脂、降低CIMT及改善血管内皮功能。
Objective To investigate the effect of combination of probucol and simvastatin on carotid artery intima-media thickness and vascular endothelial function in patients with acute coronary syndrome (ACS). Methods Sixty patients with acute coronary syndrome were randomly divided into simvastatin group (group A, simvastatin 40 mg / d, n = 30) and simvastatin and probucol combined treatment group (group B and group Xin (TC), LDL-C and ox-LDL in peripheral blood were measured by real-time PCR, LDL) levels, medication for 3 months, observed changes in indicators before and after treatment. The carotid artery intima-media thickness (CIMT) and brachial artery endothelium-dependent vasodilation (FMD) were detected by high-frequency ultrasound. The changes of the indexes before and after treatment were observed after 3 months of treatment. Results There was no significant difference between the two groups before treatment. The levels of TC, LDL-C, ox-LDL and CIMT in the two groups after treatment were lower than those before treatment and the FMD was improved. However, the combined treatment group decreased more significantly than the single treatment group. Conclusions Simvastatin combined with anti-oxidant therapy can further decrease blood lipid, decrease CIMT and improve endothelial function in ACS patients.