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目的 :探讨解酒灵解酒作用的机制。方法 :利用自动生化分析仪、TBA显色法、邻苯三酚自氧化法分别测定血清中ALT和AST活性及肝匀浆中丙二醛 (MDA)和超氧化物歧化酶 (SOD)活性 ;用HE染色法、PAS染色法观察肝组织形态学的病变。结果 :解酒灵能抑制乙醇所致的ALT及AST活性的升高和脂质过氧化物的升高(P <0 .0 1) ,能诱导SOD活性。结论 :解酒灵对乙醇所致鼠肝急性损伤的保护作用机制与抗自由基的产生和提高SOD活性有关
Objective: To explore the mechanism of hangover spirit hangover effect. Methods: The activity of ALT and AST in serum and the activity of malondialdehyde (MDA) and superoxide dismutase (SOD) in liver homogenate were measured by automatic biochemical analyzer, TBA colorimetry and pyrogallol autoxidation respectively. Hematoxylin-eosin staining and PAS staining were used to observe the morphological changes of liver tissue. Results: hangover spirit can inhibit the increase of ethanol induced ALT and AST activity and lipid peroxidation (P <0.01), can induce SOD activity. Conclusion: The protective mechanism of Jiejiuling on alcohol-induced acute liver injury in mice is related to the generation of anti-free radicals and the increase of SOD activity