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目的研究分析血清半胱氨酸蛋白酶抑制剂C(Cystatin C)在糖尿病肾病中的应用价值与临床意义。方法将156例糖尿病患者按白蛋白排泄率(UAER)分为3组,正常蛋白尿组(1组)42例,微量蛋白尿组(2组)60例和大量蛋白尿组(3组)54例,设立对照组(健康体检合格者)。测定各组Cystatin C、血清肌酐(Scr)、肌酐清除率(Ccr)。进而对各指标使用SPSS11.0统计软件进行比较分析和相关性分析。结果在糖尿病患者中所测的Cystatin C平均值高于对照组(P<0.05),而血清肌酐在1组和2组中所测的平均值并无明显差别,且Cystatin C与Ccr的相关性较Scr与Ccr的相关性好。结论血Cystatin C对2型糖尿病肾病的早期诊断较血清肌酐更敏感。
Objective To study the value and clinical significance of serum cystatin C in diabetic nephropathy. Methods According to the albumin excretion rate (UAER), 156 patients with diabetes mellitus were divided into three groups: 42 patients in normal proteinuria group (group 1), 60 patients in microalbuminuria group (2 patients) and 60 patients in large proteinuria group (3 patients) Example, set up a control group (health examination). Cystatin C, serum creatinine (Scr) and creatinine clearance (Ccr) were determined in each group. Then using the SPSS11.0 statistical software for each indicator for comparative analysis and correlation analysis. Results The average values of Cystatin C measured in diabetic patients were higher than those in the control group (P <0.05), while the serum creatinine values did not differ significantly between groups 1 and 2, and the correlation between Cystatin C and Ccr Relative to Scr and Ccr. Conclusion Serum Cystatin C is more sensitive to serum creatinine in early diagnosis of type 2 diabetic nephropathy.