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目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)治疗对小儿难治性哮喘的影响。方法将60例难治哮喘伴OSAHS患儿,按照随机双盲法分成两组,实验组实施手术治疗,对照组实施保守疗法。观察治疗前后患儿哮喘状态、肺功能变化,评价控制效果。结果实验组治疗后呼吸暂停低通气指数(AHI)、阻塞性呼吸暂停指数(OAI)和最低动脉血氧饱和度(LSa O2)改善效果优于对照组(P<0.05)。实验组控制有效率90.0%,高于对照组(76.7%,P<0.05)。结论难治性哮喘伴OSAHS患儿气道反应性明显增高,哮喘不易控制;积极对OSAHS进行手术治疗,有助于缓解哮喘症状,改善肺通气功能,建议临床加以重视。
Objective To investigate the effect of obstructive sleep apnea-hypopnea syndrome (OSAHS) on refractory asthma in children. Methods Sixty children with refractory asthma and OSAHS were divided into two groups according to a randomized double-blind method. The experimental group was treated by surgery and the control group was treated by conservative treatment. Observed before and after treatment in children with asthma, lung function changes, evaluate the control effect. Results The improvement of AHI, OAI and LSa O2 in the experimental group was better than that in the control group (P <0.05). Experimental group control efficiency 90.0%, higher than the control group (76.7%, P <0.05). Conclusions The airway reactivity of children with refractory asthma and OSAHS is significantly increased, and asthma is not easy to control. Active surgical treatment of OSAHS can help relieve asthma symptoms and improve pulmonary ventilation.