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肝衰竭是临床常见的严重肝病临床症候群，短期病死率高。虽然目前国际上缺乏规范统一的肝衰竭前期诊断标准，但其概念的提出对于进一步提高肝衰竭的早期预警具有十分重要的意义。现从病因学、临床实验室检查及发病机制相关参数，对肝衰竭发生风险的预警指标进行综述，旨在帮助临床医生提高对肝衰竭早期诊断的认识，推动相关研究，从而进一步降低肝衰竭患者的病死率。“,”Liver failure is a common clinical syndrome of severe liver disease, with high short-term mortality. Although there is currently no standardized and unified diagnostic criteria for pre-hepatic failure in the world, so the proposal of its concept is of great significance to further improve the prewarning of liver failure. This article reviews the prewarning parameters of the risk of liver failure related from the perspectives of etiologies, clinical laboratory tests and pathogenesis, and thereby aims to help clinicians improve their understanding of early diagnosis of liver failure and promote related research to further reduce the mortality rate of patients with liver failure.