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目的 :探讨酷似恶性组织细胞病 (m alignant histiocytosis,MH)的淋巴瘤之临床及病理学特征。方法 :对曾确诊 MH的 6例患者临床、实验室有关指标进行分析 ;对尸检、活检病理标本采用单克隆抗体免疫组化染色、HE染色和 EB病毒 (epstein- barr virus,EBV)原位杂交 (EBER- ISH)。结果 :6例患者临床、实验室及细胞形态学酷似 MH特征。尸检示 :恶性细胞侵袭广泛 ,多中心分布不均匀。免疫表型分析 :CD+ 45RO、CD+ 3ε、CD- 2 0 、CD- 6 8,提示恶性细胞属 T细胞来源而非组织细胞来源。同时所作 3例 EBER- ISH均为阳性反应。结论 :酷似 MH的淋巴瘤其恶性细胞多来源于 T细胞。EBV感染可能与发病有一定相关性
Objective: To investigate the clinical and pathological features of lymphoma resembling m alignant histiocytosis (MH). METHODS: Clinical and laboratory parameters were analyzed in 6 patients who had been diagnosed with MH. Monoclonal antibody immunohistochemical staining, HE staining, and EBV in situ hybridization were performed on autopsy and biopsy specimens. (EBER-ISH). Results: The clinical, laboratory and cell morphology of the 6 patients resembled the MH features. The autopsy showed that the invasion of malignant cells was extensive and the polycentric distribution was uneven. Immunophenotyping analysis: CD+45RO, CD+3[epsilon], CD-200, CD-86, suggesting that malignant cells are of T-cell origin rather than histiocytic origin. At the same time, 3 cases of EBER-ISH were positive. Conclusion: The malignant cells resembling MH are mostly derived from T cells. EBV infection may have a certain correlation with morbidity