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目的 :改进盐酸利多卡因注射液中盐酸利多卡因的含量测定方法。方法 :采用HPLC法 ,使用C18柱 ,磷酸盐缓冲液 乙腈 (5 0∶5 0 ,pH8.0 )为流动相 ,检测波长 :2 5 4nm。结果 :此方法线性关系良好 ,盐酸利多卡因平均加样回收率为 99.5 % ,RSD为 0 .5 %。结论 :该法操作简单 ,结果准确 ,可用于盐酸利多卡因注射液中盐酸利多卡因的含量测定。
Objective: To improve the determination of lidocaine hydrochloride in injection of lidocaine hydrochloride. Methods: The mobile phase consisted of C18 column, phosphate buffer acetonitrile (50:50, pH 8.0) and detection wavelength of 254 nm by HPLC method. Results: The linearity of this method was good. The average recovery of lidocaine hydrochloride was 99.5% with RSD of 0.5%. Conclusion: The method is simple, accurate and can be used for the determination of lidocaine hydrochloride in injection of lidocaine hydrochloride.