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目的:对在我院接种乙肝疫苗儿童的接种效果进行观察。方法:选择在我院接种乙肝疫苗的儿童共计1690例,对其中1656份有效的血清应用酶联免疫吸附试验法进行临床检测,对疫苗的注射效果进行观察并评价。结果:在本组中,已免疫儿童的HBsAg标化阳性率为0.3%,抗-HBs的标化阳性率达到了65.3%,随着年龄的不断增长,1岁至3岁以及5岁以上的儿童其抗-HBs阳性率呈现出下降的趋势(P<0.05);加强接种乙肝疫苗的儿童其抗-HBs阳性率达到了73.8%,明显高于未加强组的47.3%(P<0.05)。结论:在对儿童进行乙肝疫苗接种之后,儿童的HBsAg携带率出现了明显的降低,对免疫加强之后,能够使得抗-HBs阳性率出现明显的上升,提高免疫的效果,值得临床推广并应用。
Objective: To observe the effect of inoculation of hepatitis B vaccine in our hospital. Methods: A total of 1690 children were selected to inoculate hepatitis B vaccine in our hospital. 1656 validated serum samples were tested by enzyme-linked immunosorbent assay (ELISA). The injection effect was observed and evaluated. Results: In this group, the positive rate of HBsAg in immunized children was 0.3% and the positive rate of anti-HBs was 65.3%. With the increasing of age, 1 to 3 years old and 5 years old The positive rate of anti-HBs in children showed a decreasing trend (P <0.05). The positive rate of anti-HBs in children vaccinated with hepatitis B vaccine reached 73.8%, significantly higher than that in the non-booster group (47.3%, P <0.05). CONCLUSION: After HBsAg vaccination in children, the incidence of HBsAg in children shows a significant decrease. After the immunity is strengthened, the positive rate of anti-HBs can be significantly increased and the immune effect can be improved. Therefore, it is worthy of clinical promotion and application.