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在“世界屋脊”—青藏高原,世代生活的藏族人群经过长期的自然选择已能较好地适应高原环境,其耐受低氧的生理生化改变如红细胞增多、血管数量和血容量增加、血管收缩增强等相关问题已成为近年来的研究热点。但这些变化一方面增强了世居高原藏族人群的低氧耐受能力,另外一方面也增加了藏族人群心血管事件的发生率。此外,除了高原不同海拔高度血氧饱和度不同程度降低(海拔每增加300 m,机体血氧饱和度下降1%)外[1],藏族人
In the “roof of the world” - the Tibetan population living in the Qinghai-Tibet Plateau, after long-term natural selection, has been able to adapt well to the plateau environment. Physiological and biochemical changes that tolerate hypoxia such as increased red blood cells, increased blood vessels and blood volume, Vasoconstriction and other related issues have become the research hot spots in recent years. However, these changes not only enhanced the hypoxia tolerance of Tibetans in the plateau on the one hand, but also increased the incidence of cardiovascular events in the Tibetan population on the other hand. In addition, in addition to different degrees of oxygen saturation at different altitudes (altitude of 300 m, body oxygen saturation decreased by 1%) at different altitudes [1], Tibetans