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目的:评价左氧氟沙星治疗慢性支气管炎(Chronic Bronchitis,CB,简称慢支)临床疗效,对比不同剂量用药水平治疗疗效、起效特点。方法:本组72例患者,收治于2013年7月~2014年8月,均给予左氧氟沙星治疗,采用随机队列插入法,其中36例患者,100mg/次,3次/d,纳入小剂量组,36例患者,200mg/次,2次/d,纳入大剂量组,对比相关指标。结果:第5d,小剂量组与大剂量组体温、咳嗽、咳痰、浓痰、喘息、总分低于治疗前,大剂量组体温、喘息、总分低于小剂量组,差异具有统计学意义(P<0.05);大剂量组显效率、有效率、无效率分别69.4%、27.8%、2.8%,小剂量组分别为50.0%、27.8%、22.2%,大剂量组痰培养阳性率0.00%低于小剂量组16.67%,差异具有统计学意义(P<0.05);5d后,小剂量组、大剂量组FEV1水平高于治疗前,WBC低于治疗前,大剂量组WBC低于小剂量组,差异具有统计学意义(P<0.05);两组均未见严重不良反应,两组不良反应发生率均为5.56%,均为差异无统计学意义(P>0.05)。结论:左氧氟沙星治疗慢支临床疗效较好,大剂量用药抗感染疗效更好,更有助于缩短病程,促患者及早康复,对于预防并发症具有积极意义。
OBJECTIVE: To evaluate the clinical efficacy of levofloxacin in the treatment of chronic bronchitis (chronic bronchitis) and to compare the efficacy and efficacy of different doses of levofloxacin in the treatment of chronic bronchitis. Methods: Totally 72 patients in our hospital were treated with levofloxacin from July 2013 to August 2014. All the patients were treated by random cohort, including 36 patients (100mg / time, 3 times / d) 36 patients, 200mg / time, 2 times / d, into the high-dose group, comparing the relevant indicators. Results: On the 5th day, the body temperature, cough, expectoration, phlegm, wheezing, total score of low-dose group and high-dose group were lower than those of low-dose group and high-dose group (P <0.05). The effective rate, effective rate and ineffective rate of high dose group were 69.4%, 27.8% and 2.8% respectively, and those of low dose group were 50.0%, 27.8% and 22.2% respectively. The positive rate of sputum culture in high dose group was 0.00 % Lower than the low dose group 16.67%, the difference was statistically significant (P <0.05); 5d after the low-dose group, high-dose FEV1 levels were higher than before treatment, WBC was lower than before treatment, high-dose group was lower than WBC Dose group, the difference was statistically significant (P <0.05); no serious adverse reactions were found in both groups, the incidence of adverse reactions in both groups were 5.56%, all of which showed no significant difference (P> 0.05). Conclusion: Levofloxacin has a good curative effect on chronic bronchitis. The anti-infective effect of large dose of anti-infective drug is better, which will help to shorten the course of the disease and promote early recovery. It is of great significance for the prevention of complications.