液体流动诱导的切应力所引起的细胞生物学改变是目前许多细胞研究领域的热点。既往研究主要集中于血流诱导的切应力在调节内皮细胞功能中的作用。最近研究发现,在肾脏的近端小管上皮细胞,由尿液流动诱导的切应力对其具有多效性,如调节溶质的转运、影响细胞骨架的重组、改变细胞外基质的重塑及调节选择性基因和蛋白质的表达等。管流诱导的肾近端小管上皮细胞生物学改变的机制仍不清楚,可能与细胞骨架肌动蛋白的重排有关。 The biological changes induced by fluid-induced shear stress are the hot topics in many cell research fields. Previous studies have focused on the role of blood flow-induced shear stress in regulating endothelial function. Recent studies have found that in proximal tubular epithelial cells of the kidney, shear stress induced by urine flow has pleiotropic effects on them, such as regulating the transport of solutes, affecting cytoskeletal reorganization, altering the extracellular matrix remodeling and modulating the selection Sex gene and protein expression and so on. The mechanism of tubular-induced biological changes of renal proximal tubular epithelial cells remains unclear and may be related to the rearrangement of cytoskeletal actin.