新生儿坏死性小肠结肠炎(NEC)是新生儿最常见的胃肠道急症,在全世界范围内已成为新生儿高发病率和高病死率的主要原因。新生儿重症监护病房(NICU)中早产儿和大多数疑似被感染的足月儿均接受抗菌药物预防治疗。已有大量研究探讨NEC、败血症和抗菌药物之间的关系。本文就近年来有关治疗及预防NEC并发败血症经验性使用抗菌药物研究进展作一综述。 Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in newborns and has been a leading cause of high neonatal morbidity and mortality worldwide. Prenatal neonatal intensive care unit (NICU) and most of the suspected full-term infants were infected with antimicrobial prophylaxis. Numerous studies have been conducted to investigate the relationship between NEC, sepsis and antimicrobial agents. This review summarizes the recent progress in the research on the prevention and treatment of NEC associated sepsis.