In this study,bimetallic nanoscale zero-valent iron particles (nZVI),including copper/ nanoscale zero-valent iron particles (Cu/nZVI) and nickel/nanoscale zero-valent iron particles (Ni/nZVI),were synthesized by one-step liquid-phase reduction and applied for oxytetracycline (OTC) removal.The effects of contact time and initial pH on the removal efficiency were studied.The as-prepared nanoscale particles were characterized by scanning electron microscopy (SEM),energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD).Finally,the degradation mechanisms of OTC utilizing the as-prepared nanoparticles were investigated by using X-ray photoelectron spectroscopy (XPS) and mass spectrometry (MS).Cu/nZVI presented remarkable ability for OTC degradation and removed 71.44％ of OTC (100 mg/L) in 4 hr,while only 62.34％ and 31.05％ of OTC was degraded by Ni/nZVI and nZVI respectively.XPS and MS analysis suggested that OTC was broken down to form small molecules by.OH radicals generated from the corrosion of Fe0.Cu/nZVI and Ni/nZVI have been proved to have potential as materials for application in OTC removal because of their significant degradation ability toward OTC.