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目的:探讨妊娠期合并生殖道人乳头瘤病毒(HPV)感染对妊娠结局和新生儿的影响,总结其临床疗效及体会。方法:选择温岭市妇幼保健院2013年1月-2013年9月55例妊娠期生殖道HPV感染患者为研究对象,对其临床病历资料进行回顾性分析,以同期85例未感染HPV的妊娠妇女为对照。结果:1妊娠期妇女HPV感染率39.3%,其中15例(27.3%)临床感染,22例(40%)亚临床感染,16(29.1%)潜伏性感染;2两组妊娠结局无统计学差异(P>0.05),研究组不同分娩方式妊娠结局无统计学差异(P>0.5);3两组早产、胎膜早破、胎儿生长受限、新生儿呼吸窘迫、产后出血及产褥感染发生率无统计学意义(P>0.05);4研究组新生儿HPV感染11例(23.4%),不同分娩方式羊水、脐血、胎盘及咽喉分泌物HPV阳性率比较均无统计学意义(P>0.05)。结论:妊娠合并下生殖道HPV感染可母婴垂直传播,对妊娠结局影响不大;不同分娩方式对新生儿HPV阳性率无显著影响;高危型HPV感染是浸润性宫颈癌的危险因素,妊娠期妇女应加强早期筛查并治疗。
Objective: To investigate the effect of pregnancy-associated human papillomavirus (HPV) infection on pregnancy outcome and neonatal outcome and to summarize its clinical efficacy and experience. Methods: From January 2013 to September 2013, 55 cases of genital tract HPV infection during pregnancy in Wenling Maternal and Child Health Hospital were selected as the research objects. The clinical medical record data were retrospectively analyzed. In the same period, 85 pregnant women without HPV infection As a control. Results: 1 The prevalence of HPV infection in pregnant women was 39.3%, of which 15 (27.3%) were clinically infected, 22 (40%) were subclinical and 16 (29.1%) were latent infection. The pregnancy outcome was not statistically different between the two groups (P> 0.05). There was no significant difference in the outcome of pregnancy between different delivery methods in the study group (P> 0.5) .3 The incidence of preterm labor, premature rupture of membranes, fetal growth restriction, neonatal respiratory distress, postpartum hemorrhage and puerperal infection occurred in both groups (P> 0.05). In the study group, 11 cases (23.4%) were newborns with HPV infection. The positive rate of HPV in amniotic fluid, umbilical cord blood, placenta and throat secretions in different modes of delivery had no statistical significance (P> 0.05). Conclusion: The HPV infection of lower genital tract in pregnancy can be transmitted vertically by mother and infant, and has little effect on pregnancy outcome. Different modes of delivery have no significant effect on HPV positive rate. High-risk HPV infection is a risk factor for invasive cervical cancer. Women should strengthen early screening and treatment.