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目的观察替米沙坦治疗老年原发性高血压病(EH)的临床疗效。方法 120例老年EH患者服用替米沙坦80mg/d,疗程4周。并测定其血糖、血脂、肝功、肾功及心率变化情况。结果 60例老年高血压患者治疗4周后与治疗前比较,患者血压明显下降,治疗前为(164.45±11.73)/(84.35±14.65)mmHg,治疗后降为(132.74±7.47)/(72.10±6.56)mmHg(P<0.01)。脉压亦有明显缩小(P<0.01),有不良反应者7例,主要为腹痛、腹泻、消化不良、关节痛、肌痛等,症状较轻不需停药。结论替米沙坦治疗老年EH疗效好、耐受性好、副作用少。
Objective To observe the clinical efficacy of telmisartan in the treatment of senile essential hypertension (EH). Methods 120 elderly EH patients took Telmisartan 80mg / d for 4 weeks. Blood glucose, blood lipids, liver function, renal function and heart rate were measured. Results The blood pressure of 60 elderly hypertensive patients after 4 weeks of treatment was significantly lower than that before treatment (164.45 ± 11.73 / (84.35 ± 14.65) mmHg before treatment and (132.74 ± 7.47) / (72.10 ± 6.56) mmHg (P <0.01). Pulse pressure was also significantly reduced (P <0.01), there were 7 cases of adverse reactions, mainly abdominal pain, diarrhea, indigestion, joint pain, myalgia, mild symptoms without stopping. Conclusion Telmisartan treatment of elderly EH good effect, tolerability, fewer side effects.