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目的探讨Endoglin mRNA在卵巢上皮性肿瘤中表达的差异及其意义。方法采用半定量RT-PCR方法测定卵巢囊腺瘤和卵巢癌组织中的Endoglin mRNA表达。结果Endoglin mRNA在卵巢癌和卵巢囊腺瘤组织中均有表达,但卵巢癌组织中Endoglin mRNA表达水平明显高于卵巢囊腺瘤,其差异有统计学意义,病理Ⅲ级明显高于Ⅰ、Ⅱ级。结论卵巢上皮性肿瘤无论良性或恶性,均有Endoglin mRNA表达,但Endoglin mRNA在卵巢癌组织中表达水平与卵巢囊腺瘤相比明显增高。Endog-lin在卵巢癌组织中表达随着肿瘤的分化程度下降而上调,Endoglin基因在卵巢上皮性癌中的表达与肿瘤的恶性程度成正比,因而Endoglin可能与卵巢上皮肿瘤细胞恶化密切相关。
Objective To investigate the difference and significance of Endoglin mRNA expression in epithelial ovarian tumors. Methods The expression of Endoglin mRNA in ovarian cystadenocarcinoma and ovarian cancer tissues was determined by semi-quantitative RT-PCR. Results Endoglin mRNA was expressed in both ovarian cancer and ovarian cystadenocarcinoma, but the expression level of Endoglin mRNA in ovarian cancer was significantly higher than that in ovarian cystadenoma, the difference was statistically significant, the pathological grade Ⅲ was significantly higher than Ⅰ, Ⅱ level. Conclusion The expression of Endoglin mRNA in epithelial ovarian cancer, both benign and malignant, is significantly higher than that in ovarian cystadenocarcinoma. The expression of Endog-lin in ovarian cancer tissues is increased with the decrease of tumor differentiation. The expression of Endoglin in epithelial ovarian cancer is proportional to the malignancy of the tumor, so Endoglin may be closely related to the malignant ovarian tumor cells.