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癫癎是严重危害人类健康的常见病、多发病,引起癫(?)的病理机制复杂。目前一氧化氮(NO)参与癫(?)的发作已得到公认,但具体机制不明,现就NO与癫(?)的最新研究进展综述如下。1 NO的生物学特性 NO是L精氨酸(L-Arg)在一氧化氮合酶(NOS)作用下生成的,NOS主要有三种类型:Ⅰ型神经元型NOS(nNOS);Ⅱ型诱导型NOS(iNOS);Ⅲ型内皮型NOS(eNOS),nNOS和eNOS属于结构型NOS(cNOS),依赖ca2+或钙调蛋白,快速短暂生成NO。研究
Epilepsy is a common disease that seriously endangers human health, with multiple pathogenesis and complicated pathological mechanism of epilepsy (?). At present, nitric oxide (NO) is involved in the onset of epilepsy (?) Has been recognized, but the specific mechanism is unknown, the latest research progress on NO and epilepsy (?) Are summarized below. 1 NO biological characteristics of NO is L arginine (L-Arg) in nitric oxide synthase (NOS) generated under the action of NOS there are three main types: type Ⅰ neuronal NOS (nNOS); type Ⅱ induced Type III NOS (eNOS), nNOS and eNOS are constitutively typed NOS (cNOS) that rely on ca2 + or calmodulin to rapidly and transiently produce NO. the study