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:在急性心肌梗塞血管内溶栓、经皮冠状动脉内成形术、体外循环等治疗过程中 ,患者面临心肌缺血再灌注 (ischemia/reperfusion;I/ R)损伤问题。心肌 I/ R损伤涉及多种因素 ,包括氧自由基产生、Ca2 + 超负荷、血管活性物质释放、中性粒细胞的浸润 ,尤其是后者 ,因它与活化血小板、内皮细胞的相互作用 ,经级联 (cascade)反应产生大量酶、氧自由基及形成血栓 ,在心肌 I/ R损伤中起关键作用。而 P-选择素 (P- selectin;Ps)是这一系列事件的始动条件 ,因此对 Ps进行深入研究 ,对于揭示心肌 I/ R损伤机制 ,防治临床上心肌 I/ R损伤 ,具有重要意义。
: Myocardial ischemia / reperfusion (I / R) injury is a problem in the treatment of acute myocardial infarction such as endovascular thrombolysis, percutaneous transluminal coronary angioplasty and cardiopulmonary bypass. Cardiac I / R injury involves a variety of factors including oxygen free radical production, Ca2 + overload, release of vasoactive substances, infiltration of neutrophils, especially the latter, due to its interaction with activated platelets, endothelial cells, Cascade reactions produce large amounts of enzymes, oxygen free radicals and thrombus formation, which play a key role in myocardial I / R injury. P-selectin (P-selectin; Ps) is the initiating condition of this series of events, therefore, in-depth study of Ps, for revealing myocardial I / R injury mechanism, prevention and treatment of clinical myocardial I / R injury, is of great significance .