异丁酸与亚硫酰氯反应制得异丁酰氯 ,适宜的反应条件为 :异丁酸滴加温度 2 5～ 3 0℃ ,滴加时间 0 5h ;反应温度 80℃ ,反应时间 1 5h ;收率为 92 %～ 93 % .在催化剂无水三氯化铝存在下 ,甲苯与异丁酰氯进行酰基化反应得 2 甲基 1 (4 甲基苯基 )丙酮 ,收率为 75 % .合成产物经红外光谱、核磁共振谱鉴定结构正确 . Isobutyric acid and thionyl chloride reaction isobutyryl chloride, the appropriate reaction conditions: isobutyric acid dropwise temperature 25 ~ 30 ℃, dropping time 0 5h; reaction temperature 80 ℃, the reaction time of 1 5h; The yield was 92% ~ 93% .In the presence of catalyst anhydrous aluminum chloride, toluene and isobutyryl chloride were acylated to give 2 methyl 1 (4 methylphenyl) acetone in 75% yield. The structure was confirmed by IR and NMR.