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目的分析心原发性卵黄囊瘤临床病理特征及诊断、鉴别诊断要点。方法对1例发生于心的肿瘤进行组织形态学观察和免疫组化研究,结合文献探讨其病理组织特征。结果镜下见肿瘤细胞呈立方、柱状,核深染,大小不一,有异型。瘤细胞形成微囊、乳头状结构,可见SD小体、透明小体及出血、坏死。免疫组化显示CK、PLAP、AFP和AAT(+),PAS亦(+)。结论心原发性卵黄囊瘤非常罕见,由于其临床表现无特异性,早期诊断困难,诊断主要依赖于组织形态学及免疫组化检查。
Objective To analyze the clinical and pathological features of primary yolk sac tumor and the main points of diagnosis and differential diagnosis. Methods One case of cardiac tumor was observed by histomorphology and immunohistochemistry. The pathological features of the tumor were analyzed with literature. Results of microscopic tumor cells showed cubic, columnar, nuclear stained, different sizes, there are irregular. The formation of tumor cells microcapsules, papillary structures, visible SD body, transparent body and bleeding, necrosis. Immunohistochemistry showed CK, PLAP, AFP and AAT (+), PAS also (+). Conclusions Cardiac primary yolk sac tumor is very rare. Because of its nonspecific clinical manifestations, early diagnosis is difficult. The diagnosis mainly depends on histomorphology and immunohistochemistry.