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结核病是伴随人类历史最长,造成人类死亡最多的慢性传染病~([1])。据WHO的最新估计,全球现有活动性肺结核病患者1200万,每年新发结核病患者870万例,有近90万人死于结核病~([2])。预防结核病的主要措施包括控制传染源、化学预防和接种结核病疫苗。1卡介苗简史卡介苗(BCG),是由法国医学家卡尔梅特(Calmette)和兽医学家介朗(Guérin)将有毒力的牛型结核分枝杆菌在甘油牛
Tuberculosis is a chronic infectious disease with the longest human history and the most human deaths. ([1]). According to the latest WHO estimates, there are 12 million active TB patients in the world, 8.7 million new TB cases occur annually, and nearly 900,000 people have died of tuberculosis ~ ([2]). The main measures to prevent tuberculosis include controlling sources of infection, chemical prevention and vaccination against tuberculosis. A brief history of BCG Bacille Calmette-Guerin (BCG) is a combination of BCG, which was produced by the French physician Calmette and the veterinary scientist Guérin,