论文部分内容阅读
目的评估去甲长春花碱 (NVB)与顺铂 (DDP)联合的NP方案在治疗晚期非小细胞肺癌 (NSCLC)的疗效与毒性反应。方法 34例NSCLC患者采用NP方案治疗 ,其治疗剂量 :NVB 2 5～ 30mg/m2 ,静注第 1、8天 ;DDP 75～ 10 0mg/m2 /周期 ,静滴第 1、2、3天 (配合水化 ) ,2 1天为 1个周期 ,至少化疗 2个周期。结果 34例患者中无一例CR ,16例PR ,有效率 4 7.0 % (16 / 34) ,13例稳定 ,5例进展。 1年生存率 39% ,中位疾病进展时间 (TTP) 5 .8个月 ,中位生存时间 9.2个月 ,主要毒性为骨髓抑制和消化道反应 ,34例患者中 ,白细胞下降 30例 (88% ) ,其中Ⅲ、Ⅳ度为 14例 (4 1% ) ,以恶心、呕吐反应突出者 31例 (91.2 % ) ,无一例Ⅳ度消化道反应。结论NP方案对NSCLC有较高的有效率和较长的生存期和缓解期。可推荐为一线治疗方案。
Objective To evaluate the efficacy and toxicity of NP regimen combined with NVB and DDP in the treatment of advanced non-small cell lung cancer (NSCLC). Methods 34 NSCLC patients were treated with NP regimen. The therapeutic dose was NVB 25 ~ 30mg / m 2, intravenously on days 1 and 8, DDP 75 ~ 100mg / m 2 / cycle, With hydration), 21 days for a period of at least 2 cycles of chemotherapy. Results None of the 34 patients had CR, 16 had PR, and the effective rate was 4 7.0% (16/34). Thirteen patients were stable and 5 patients progressed. The 1-year survival rate was 39%, the median time to progression (TTP) was 5.8 months, and the median survival time was 9.2 months. The main toxicity was myelosuppression and gastrointestinal reactions. Thirty patients (88%) had leukopenia %), Of which Ⅲ and Ⅳ degrees were 14 cases (41%), nausea and vomiting were prominent in 31 cases (91.2%), no case of Ⅳ degree digestive tract reaction. Conclusion NP regimen has a higher effective rate and longer survival and remission stage in NSCLC. May be recommended for first-line treatment.