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目的:探讨山大颜对老年痴呆模型小鼠的作用。方法:采用跳台法分别测定不同剂量(50,200 mg·kg~(-1))山大颜提取物的抗老年痴呆活性。并对小鼠的血清超氧化物歧化酶(SOD)和脑内乙酰胆碱转移酶(ChAT)酶活力进行了测定。结果:山大颜能增强小鼠的记忆,并改善老年痴呆模型小鼠的血清SOD酶和脑内ChAT酶活力(P<0.01)。结论:山大颜有抗老年痴呆的作用。
Objective: To investigate the effect of Shan Da Yan on Alzheimer’s disease model mice. Methods: The anti-Alzheimer’s disease activity of Da Yan Yan (50,200 mg · kg ~ (-1)) was determined by step-down method. The activities of serum superoxide dismutase (SOD) and acetylcholinesterase (ChAT) in mice were measured. Results: Da Yan can enhance the memory of mice and improve the activity of SOD and the activity of ChAT (P <0.01) in mice with Alzheimer’s disease. Conclusion: Hill Da Yan anti-Alzheimer’s role.