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目的观察中药清肺止痉活血方联合阿奇霉素治疗小儿支原体肺炎(MPP)痰热闭肺证的临床疗效及其对血小板(PLT)、D-二聚体的影响。方法将60例患儿随机分为治疗组和对照组各30例,治疗组采用中药清肺止痉活血方联合阿奇霉素静脉滴注;对照组仅采用阿奇霉素静脉滴注,2组均辅以西医对症治疗。比较2组患儿治疗前后主要、次要症状体征评分,血小板(PLT)、C反应蛋白(CRP)、凝血四项(PT、APTT、FIB、TT)、D-聚体,以及临床总疗效。结果 2组总体疗效,咳嗽、痰壅、气喘、听诊啰音等主症,精神、面色、食欲食量、口渴等次症,以及PLT、D-二聚体、FIB等指标,组间比较差异均有统计学意义(P<0.05)。结论清肺止痉活血法联合阿奇霉素治疗痰热闭肺证MPP,可改善和预防患儿的高凝状态,提高临床疗效。
Objective To observe the clinical efficacy of Qingfeizhiqi Huoxue Recipe combined with azithromycin in the treatment of Mycoplasma pneumoniae of sputum in children with Mycoplasma pneumonia (MPP) and its effect on platelet (PLT), D-dimer. Methods Sixty children were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Qingfei Zhijing Decoction and azithromycin intravenously. The control group was treated with azithromycin only. treatment. The scores of major and minor symptoms and signs, platelet (PLT), C-reactive protein (CRP), coagulation factors (PT, APTT, FIB, TT) and D-dimer before and after treatment in both groups were compared. Results The main symptoms, such as cough, phlegm, asthma, auscultation and auscultation, spirit, facial expression, appetite appetite, thirsty and other symptoms, as well as PLT, D-dimer and FIB in the two groups were compared between the two groups All were statistically significant (P <0.05). Conclusion Qingfei Zhijing and blood combined with azithromycin treatment of phlegm and lung closed card MPP can improve and prevent hypercoagulable state in children and improve clinical efficacy.