目的　研究氨基胍 (AG)在重度失血性休克中的治疗效果。方法　采用兔失血性休克 复苏模型 ,分为休克组、AG组 (复苏时应用AG) ,观察休克前后血浆内毒素 (ET)、肿瘤坏死因子(TNF) α、白细胞介素 (IL) 6、IL 8、一氧化氮 (NO)的变化 ,观察动物 2 4、48h存活率。结果　兔失血性休克后 ,血浆内毒素、TNF α、IL 6、IL 8、NO水平明显升高 ;复苏后 ,AG组动物血浆中上述物质水平明显低于休克组 ,该组动物的存活率明显高于休克组。结论　内毒素血症、TNF α、IL 6、IL 8、NO在失血性休克的发展过程中起着重要作用 ,AG作为诱导型一氧化氮合酶 (iNOS)抑制剂 ,有助于改善重度失血性休克的预后。 Objective To study the therapeutic effect of aminoguanidine (AG) in severe hemorrhagic shock. Methods Rabbit hemorrhagic shock and resuscitation models were divided into shock group and AG group. The levels of plasma endotoxin (ET), tumor necrosis factor (TNF) α, interleukin (IL) 6, IL The changes of nitric oxide (NO) and the survival rate of animals at 2 and 48 hours were observed. Results After hemorrhagic shock in rabbits, the levels of plasma endotoxin, TNFα, IL 6, IL 8 and NO were significantly increased. After resuscitation, the levels of these substances in plasma of AG animals were significantly lower than those in shock animals, and the survival rate of animals in this group was significantly Higher than the shock group. Conclusions Endotoxemia, TNFα, IL 6, IL 8 and NO play an important role in the development of hemorrhagic shock. As an inhibitor of inducible nitric oxide synthase (iNOS), AG can help to improve severe blood loss Prognosis of sexual shock.