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目的 :探索在诱发听性脑干电位 (ABR)测试中 ,增加刺激声的重复率所产生的效应 ,以早期发现高脂血症 (HL)在心、脑和耳症状发生之前引起脑干血管性病变的可能性。方法 :随机选择听力与血压正常、无心脑症状的原发性HL患者 30例 (HL组 )及正常健康者 30例 (对照组 ) ,分别用短声重复率 10、5 0次 /s作ABR测试。结果 :刺激声重复率为 10、5 0次 /s时 ,两组Ⅰ、Ⅲ、Ⅴ波潜伏期差异无显著性意义 (P >0 .0 5 ) ;重复率为 10次 /s时 ,两组 3项波间潜伏期差 (IPLD)差异无显著性意义 (P >0 .0 5 ) ,重复率增至 5 0次 /s时 ,两组 3项IPLD值差异有显著性意义 (P分别 <0 .0 1、0 .0 5、0 .0 1)。HL患者中 ,视网膜动脉硬化组与无视网膜动脉硬化组在重复率为5 0次 /s时 ,Ⅰ、Ⅲ、Ⅴ波潜伏期差异无显著性意义 (P >0 .0 5 ) ;而 3项IPLD值的差异有极显著性意义 (P <0 .0 1)。结论 :提示增加短声刺激重复率可使ABR检测敏感化 ,从而揭示可能存在的亚临床的脑干血管硬化病变
OBJECTIVE: To explore the effect of increasing the repetition rate of stimuli in the induction of auditory brainstem response (ABR) to detect early hyperlipidemia (HL) in the brainstem before vascular, cerebral and auricular symptoms The possibility of disease. Methods: Thirty patients (HL group) with normal hearing and normal blood pressure without any heart and brain symptoms and 30 healthy controls (control group) were randomly selected and treated with short-sound repetition rate of 10,5 0 times / s ABR test. Results: There was no significant difference in the latency of Ⅰ, Ⅲ, Ⅴ wave between the two groups when the repetition rate of stimulation was 10,5 0 / s (P> 0.05); when the repetition rate was 10 times / s, There were no significant differences in IPLD between the three groups (P> 0.05). When the repetition rate was increased to 50 times / s, there were significant differences in the three IPLD values between the two groups (P <0 .0 1,0 .0 5,0 .0 1). There was no significant difference in the latency of Ⅰ, Ⅲ and Ⅴ wave between HL group and non-retinal atherosclerosis group at the repetition rate of 50 times / s (P> 0.05) The difference between the values was significant (P <0.01). CONCLUSIONS: It is suggested that increasing the short-term stimulation repetition rate may sensitize ABR detection to reveal possible subclinical lesions of the brain stem sclerosis