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目的研究Survivin和Caspase-3在胃间质瘤中表达情况及临床意义。方法用免疫组化法检测57例胃间质瘤和相应的56例光镜下阴性切缘组织及10例正常胃组织的Survivin和Caspase-3的表达情况,并进行相关的研究。结果胃间质瘤中Survivin表达呈核型和核浆型,阳性率为75.4%,胃间质瘤的光镜下阴性切缘组织为3.6%,正常胃组织无表达;胃间质瘤中Caspase-3表达呈浆型,阳性率为33.3%,胃间质瘤的光镜下阴性切缘组织为82.1%,正常胃组织为80.0%。结论Survivin在胃间质瘤中表达明显高于正常组织,与核分裂象和危险度正相关,可望作为一预后因素;Caspase-3在胃间质瘤中的表达明显低于正常组织;Survivin可能通过抑制Caspase-3的表达,从而抑制胃间质瘤的凋亡,这可能在胃间质瘤的发生发展过程中起了作用。
Objective To investigate the expression of Survivin and Caspase-3 in gastric stromal tumors and its clinical significance. Methods The expressions of Survivin and Caspase-3 in 57 cases of gastric stromal tumors and corresponding 56 cases of negative marginal tissues under light microscope and 10 cases of normal gastric tissues were detected by immunohistochemistry and related studies were carried out. Results The expression of Survivin in gastric stromal tumors was karyotype and nuclear plasma. The positive rate was 75.4%. The negative margins of gastric stromal tumors were 3.6% and no expression was found in normal gastric tissues. Caspase -3 expression was plasma type, the positive rate was 33.3%. The negative margins of gastric stromal tumors were 82.1% under light microscopy and 80.0% from normal gastric tissues. Conclusions The expression of Survivin in gastric stromal tumors is significantly higher than that in normal tissues, which is positively correlated with mitotic figures and risk, which is expected to be a prognostic factor. The expression of Survivin in gastric stromal tumors is significantly lower than that in normal tissues. Survivin may By inhibiting the expression of Caspase-3, thus inhibiting the apoptosis of gastric stromal tumors, which may play a role in the occurrence and development of gastric stromal tumors.