目的:探讨氟比洛芬酯复合地佐辛对高度尼古丁依赖患者术后疼痛的影响。方法:择期全身麻醉腹腔镜胆囊切除的高度尼古丁依赖男性患者100例，ASA分级Ⅰ、Ⅱ级，采用随机数字表法将患者分为4组（每组25例）：对照组（C组）、地佐辛组（D组）、氟比洛芬酯组（F组）、地佐辛＋氟比洛芬酯组（DF组）。麻醉诱导前，C组给予等容量生理盐水，D组静脉注射地佐辛0.2 mg/kg，F组静脉注射氟比洛芬酯2 mg/kg，DF组静脉注射地佐辛0.1 mg/kg＋氟比洛芬酯l mg/kg。评估入PACU即刻（Tn 1）、入PACU 15 min(Tn 2）、离开PACU(Tn 3）、术后24 h(Tn 4）的VAS评分和布氏舒适评分（Bruggrmann Comfort Scale, BCS），记录各组患者手术时间、麻醉时间、苏醒时间、拔管时间、PACU停留时间，术后各时点VAS与BCS评分，术后补救地佐辛、恶心呕吐、嗜睡的发生率。n 结果:4组患者手术时间、麻醉时间、苏醒时间、拔管时间、PACU停留时间比较，差异无统计学意义（n P> 0.05）。C组Tn 1、Tn 2、Tn 4时VAS评分高于D组、F组和DF组（n P0.05). The VAS score in group C was significantly higher than that in group D, group F, and group DF at Tn 1 and Tn 2 (n P<0.05). The VAS score in group C was higher than that in group F and group DF at Tn 3 (n P<0.05). The VAS score in group C was higher than that in group D, group F and group DF at Tn 4 (n P<0.05). The VAS score in group DF was lower than that in group D and group F (n P<0.05). The BCS score was lower in group C than in other three groups at each time point (n P<0.05). The BCS score in group DF was higher than that in group D and group F at Tn 4 (n P<0.05). The incidence of postoperative remedial dezocine in group C was higher than that in group D, group F and group DF (n P<0.05), and the incidence of postoperative remedial dezocine in group F was higher than that in group DF (n P<0.05). The incidence of drowsiniss in group D was higher than that in group C and group DF (n P0.05).n Conclusions:The combination of flurbiprofen axetil and dezocine has a better effect on postoperative pain in patients with nicotine high-dependence and can improve patient comfort and satisfaction.